Poughkeepsie, NY Italian Restaurant

Main Street Pizza & Cafe

Serving Beer and Wine

Come experience delicious homemade Italian dishes, pizza ,pasta, and panini.

  • Dine-In
  • Take-out
  • Delivery
  • Catering

Pizza - Poughkeepsie,  NY - Main Street Pizza & Cafe - pizza - Contact Us About Our Daily Specials!

Learn More About Main Street Pizza & Cafe:

  • Appetizers
  • Soups and Salads
  • Pasta
  • Baked Dishes
  • Dinner Entrees
  • Calzones and Rolls
  • Hot and Cold Heroes
  • Wraps and Paninis
  • Flatbreads
  • Pizza
  • Desserts
  • Free delivery - minimum $12 order

We offer a full Italian menu including pizza. Contact Main Street Pizza & Cafe today at 845-849-0256.

Contact Information



Main Street Pizza & Cafe - 283 Main St Poughkeepsie,  NY  12601-3107
Main Street Pizza & Cafe
283 Main Street
Poughkeepsie, NY 12601

Click here to view our full menu
Click here to view our full catering menu
Click here for out Take-Out Menu (Prices are subject to change)
Hours of Business:
Monday- Friday 10:00am to 8:00pm
Saturday 11:00am to 8:00pm
Sunday Closed
Methods of Payment:
MasterCard Visa American Express Discover